Deric Poston on the Joe Rogan Experience: The Future of Precision Medicine

Ever wonder what the future of healthcare looks like? Joe Rogan dives deep with Deric Poston, a true visionary in the field of precision medicine. Poston, the CEO of Senda Biosciences, brings a wealth of knowledge about using nature-inspired technology to revolutionize how we treat diseases. Get ready to explore mRNA 2.0, the power of interspecies communication, and a whole new world of therapeutic possibilities. This episode is a mind-blowing journey into the cutting edge of biology and medicine!

TL;DR

Deric Poston explains how Senda Biosciences is leveraging interspecies communication and natural nanocarriers to deliver therapeutic payloads with unprecedented precision.
The conversation explores the potential of “mRNA 2.0” to create more stable and effective mRNA therapies.
Poston discusses the importance of targeting specific tissues and cells to minimize side effects and maximize therapeutic impact.
Joe and Deric delve into the ethical considerations surrounding advanced biotechnology.
Senda’s work could revolutionize treatment for a wide range of diseases, including cancer, autoimmune disorders, and genetic diseases.

Key Topics Covered

The Power of Natural Nanocarriers

Deric Poston explains that Senda Biosciences is built upon the groundbreaking concept of using naturally occurring nanocarriers, specifically those involved in interspecies communication, to deliver therapeutic payloads. These nanocarriers, derived from the complex interactions between different species, offer a highly targeted and efficient way to get drugs where they need to go within the body. This approach drastically differs from traditional methods that often lack precision and can lead to off-target effects.

He emphasizes that these nanocarriers have evolved over millions of years to be incredibly effective at crossing biological barriers and delivering their cargo to specific cells and tissues. This precision is key to minimizing side effects and maximizing the therapeutic impact of drugs. What I found particularly interesting was the idea that nature already holds the solutions to many of our medical challenges, and we’re just beginning to unlock its potential.

“Nature has already solved the problem of how to deliver things with incredible precision. We’re just learning how to harness that.” – Deric Poston

mRNA 2.0 and the Future of mRNA Therapies

The discussion then shifted to the evolution of mRNA therapies, with Poston outlining his company’s work on “mRNA 2.0.” This next generation approach aims to create more stable and effective mRNA molecules, improving their ability to reach target cells, resist degradation, and produce the desired therapeutic effect. Traditional mRNA vaccines, while effective, have limitations in terms of stability and delivery. mRNA 2.0 seeks to overcome these challenges, paving the way for broader applications of mRNA technology beyond vaccines.

Poston explains that optimizing the structure and composition of mRNA molecules can significantly enhance their performance. This includes modifications to the mRNA sequence itself, as well as the addition of protective elements that prevent degradation and improve cellular uptake. He also touched upon the crucial role of nanocarriers in delivering mRNA molecules to the right location within the body. It’s fascinating to consider the possibilities this opens for treating diseases at the genetic level.

Targeted Therapies and Minimizing Side Effects

A major focus of the conversation was the importance of developing therapies that are highly targeted to specific tissues and cells. Poston argues that this is essential for minimizing side effects and maximizing therapeutic efficacy. By delivering drugs directly to the site of disease, it’s possible to reduce the overall dose required and avoid exposing healthy tissues to harmful substances. One thing that really stood out was how much emphasis he placed on this.

He gave examples of how this approach could revolutionize the treatment of diseases like cancer, where traditional chemotherapy often damages healthy cells along with cancerous ones. With targeted therapies, it’s possible to selectively kill cancer cells while sparing healthy tissue, leading to fewer side effects and better patient outcomes. Deric highlights that this strategy of targeting the problematic part of the body is far more beneficial than broad medication application.

“The future of medicine is about precision. It’s about delivering the right treatment to the right patient at the right time, with minimal side effects.” – Deric Poston

Intriguing Anecdotes & Stories

Deric shared an engaging story about the discovery of the nanocarriers they are using at Senda Biosciences. Apparently, they initially observed these particles during research on gut microbiomes and the communication between bacteria and human cells. He explained that the surprising and unexpected realization that these particles could be harnessed for drug delivery opened up a whole new avenue of research and ultimately led to the formation of Senda Biosciences. This kind of serendipitous discovery highlights the importance of open-mindedness and curiosity in scientific exploration.

He also recounted an anecdote about the challenges of scaling up the production of these natural nanocarriers. He explained that they had to develop innovative methods for isolating and purifying these particles from complex biological samples, which required a combination of cutting-edge technology and old-fashioned ingenuity. The story illustrated the practical hurdles that researchers often face when translating scientific discoveries into real-world applications.

Conclusion

Overall, this episode of the Joe Rogan Experience offers a fascinating glimpse into the future of precision medicine. Deric Poston’s insights into interspecies communication, mRNA 2.0, and targeted therapies are both informative and inspiring. The conversation is particularly relevant to anyone interested in the cutting edge of biotechnology, the future of healthcare, or the potential of nature-inspired solutions to address complex medical challenges. It’s a must-listen for those who are keen to understand how biology and technology are converging to create a new era of personalized and effective treatments.

Watch the Full Episode

Want to dive even deeper into the world of precision medicine? Watch the full episode to hear the entire conversation between Joe Rogan and Deric Poston!

Joe Rogan Experience #2306 - Deric Poston on YouTube Joe Rogan Experience #2306 – Deric Poston on YouTube